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    Temporal recording of mammalian growth and precancer – Nature

  • Tanay, A. & Regev, A. Scaling single-cell genomics from phenomenology to mechanism. Nature 541, 331–338 (2017).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Burrill, D. R. & Silver, P. A. Making mobile reminiscences. Cell 140, 13–18 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Church, G. M., Gao, Y. & Kosuri, S. Subsequent-generation digital info storage in DNA. Science 337, 1628 (2012).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Sheth, R. U. & Wang, H. H. DNA-based reminiscence units for recording mobile occasions. Nat. Rev. Genet. 19, 718–732 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Park, J. et al. Recording of elapsed time and temporal details about organic occasions utilizing Cas9. Cell 184, 1047–1063 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kaufman, M. H. Atlas of Mouse Growth (Educational, 1992).

  • Sulston, J. E. & Horvitz, H. R. Publish-embryonic cell lineages of the nematode, Caenorhabditis elegans. Dev. Biol. 56, 110–156 (1977).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Kaiser, S. et al. Transcriptional recapitulation and subversion of embryonic colon growth by mouse colon tumor fashions and human colon most cancers. Genome Biol. 8, R131 (2007).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bellacosa, A. Developmental illness and most cancers: organic and scientific overlaps. Am. J. Med. Genet. A 161a, 2788–2796 (2013).

    Article 
    PubMed 

    Google Scholar 

  • Visvader, J. E. Cells of origin in most cancers. Nature 469, 314–322 (2011).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Sprouffske, Okay., Pepper, J. W. & Maley, C. C. Correct reconstruction of the temporal order of mutations in neoplastic development. Most cancers Prev. Res. (Phila.) 4, 1135–1144 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Gerstung, M. et al. The evolutionary historical past of two,658 cancers. Nature 578, 122–128 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Heiser, C. N. et al. Molecular cartography uncovers evolutionary and microenvironmental dynamics in sporadic colorectal tumors. Cell 186, 5620–5637 (2023).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Chan, M. M. et al. Molecular recording of mammalian embryogenesis. Nature 570, 77–82 (2019).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bowling, S. et al. An engineered CRISPR-Cas9 mouse line for simultaneous readout of lineage histories and gene expression profiles in single cells. Cell 181, 1410–1422 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wagner, D. E. & Klein, A. M. Lineage tracing meets single-cell omics: alternatives and challenges. Nat. Rev. Genet. 21, 410–427 (2020).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Shin, H. Y. et al. CRISPR/Cas9 concentrating on occasions trigger advanced deletions and insertions at 17 websites within the mouse genome. Nat. Commun. 8, 15464 (2017).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Quinn, J. J. et al. Single-cell lineages reveal the charges, routes, and drivers of metastasis in most cancers xenografts. Science 371, eabc1944 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Yang, D. et al. Lineage tracing reveals the phylodynamics, plasticity, and paths of tumor evolution. Cell 185, 1905–1923 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Perli, S. D., Cui, C. H. & Lu, T. Okay. Steady genetic recording with self-targeting CRISPR-Cas in human cells. Science 353, aag0511 (2016).

    Article 
    PubMed 

    Google Scholar 

  • Kalhor, R. et al. Developmental barcoding of entire mouse through homing CRISPR. Science 361, eaat9804 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Replogle, J. M. et al. Combinatorial single-cell CRISPR screens by direct information RNA seize and focused sequencing. Nat. Biotechnol. 38, 954–961 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Dixit, A. et al. Perturb-seq: dissecting molecular circuits with scalable single-cell RNA profiling of pooled genetic screens. Cell 167, 1853–1866 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Banerjee, A. et al. Succinate produced by intestinal microbes promotes specification of tuft cells to suppress ileal irritation. Gastroenterology 159, 2101–2115 (2020).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Pijuan-Sala, B. et al. A single-cell molecular map of mouse gastrulation and early organogenesis. Nature 566, 490–495 (2019).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Saitou, M. & Yamaji, M. Primordial germ cells in mice. Chilly Spring Harb. Perspect. Biol. 4, a008375 (2012).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kobayashi, T. & Surani, M. A. On the origin of the human germline. Growth 145, e202201706 (2018).

    Article 

    Google Scholar 

  • Tzouanacou, E. et al. Redefining the development of lineage segregations throughout mammalian embryogenesis by clonal evaluation. Dev. Cell 17, 365–376 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Nowotschin, S. et al. The emergent panorama of the mouse intestine endoderm at single-cell decision. Nature 569, 361–367 (2019).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kwon, G. S., Viotti, M. & Hadjantonakis, A. Okay. The endoderm of the mouse embryo arises by dynamic widespread intercalation of embryonic and extraembryonic lineages. Dev. Cell 15, 509–520 (2008).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Zernicka-Goetz, M., Morris, S. A. & Bruce, A. W. Making a agency determination: multifaceted regulation of cell destiny within the early mouse embryo. Nat. Rev. Genet. 10, 467–477 (2009).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Ju, Y. S. et al. Somatic mutations reveal uneven mobile dynamics within the early human embryo. Nature 543, 714–718 (2017).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Bryant, P. J. & Simpson, P. Intrinsic and extrinsic management of development in growing organs. Q. Rev. Biol. 59, 387–415 (1984).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Stanger, B. Z. Organ measurement dedication and the boundaries of regulation. Cell Cycle 7, 318–324 (2008).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • van Neerven, S. M. & Vermeulen, L. Cell competitors in growth, homeostasis and most cancers. Nat. Rev. Mol. Cell Biol. 24, 221–236 (2023).

    Article 
    PubMed 

    Google Scholar 

  • Yzaguirre, A. D. & Speck, N. A. Insights into blood cell formation from hemogenic endothelium in lesser-known anatomic websites. Dev. Dyn. 245, 1011–1028 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Qiu, J. et al. Embryonic hematopoiesis in vertebrate somites offers rise to definitive hematopoietic stem cells. J. Mol. Cell Biol. 8, 288–301 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nowakowski, R. S. et al. Inhabitants dynamics throughout cell proliferation and neuronogenesis within the growing murine neocortex. Outcomes Probl. Cell Differ. 39, 1–25 (2002).

    Article 
    PubMed 

    Google Scholar 

  • Zafar, H., Lin, C. & Bar-Joseph, Z. Single-cell lineage tracing by integrating CRISPR-Cas9 mutations with transcriptomic knowledge. Nat. Commun. 11, 3055 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Tsai, Y. H. et al. LGR4 and LGR5 operate redundantly throughout human endoderm differentiation. Cell. Mol. Gastroenterol. Hepatol. 2, 648–662 (2016).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Franklin, V. et al. Regionalisation of the endoderm progenitors and morphogenesis of the intestine portals of the mouse embryo. Mech. Dev. 125, 587–600 (2008).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Barker, N. et al. Crypt stem cells because the cells-of-origin of intestinal most cancers. Nature 457, 608–611 (2009).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Guiu, J. et al. Tracing the origin of grownup intestinal stem cells. Nature 570, 107–111 (2019).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Egeblad, M., Nakasone, E. S. & Werb, Z. Tumors as organs: advanced tissues that interface with your complete organism. Dev. Cell 18, 884–901 (2010).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fearon, E. R., Hamilton, S. R. & Vogelstein, B. Clonal evaluation of human colorectal tumors. Science 238, 193–197 (1987).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Williams, M. J. et al. Identification of impartial tumor evolution throughout most cancers varieties. Nat. Genet. 48, 238–244 (2016).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Thorsen, A. S. et al. Heterogeneity in clone dynamics inside and adjoining to intestinal tumours recognized by Dre-mediated lineage tracing. Dis. Mannequin. Mech. 14, dmm046706 (2021).

    PubMed 
    PubMed Central 

    Google Scholar 

  • Chen, B. et al. Differential pre-malignant applications and microenvironment chart distinct paths to malignancy in human colorectal polyps. Cell 184, 6262–6280 (2021).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Schepers, A. G. et al. Lineage tracing reveals Lgr5+ stem cell exercise in mouse intestinal adenomas. Science 337, 730–735 (2012).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Fearon, E. R. & Vogelstein, B. A genetic mannequin for colorectal tumorigenesis. Cell 61, 759–767 (1990).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Thirlwell, C. et al. Clonality evaluation and clonal ordering of particular person neoplastic crypts exhibits polyclonality of colorectal adenomas. Gastroenterology 138, 1441–1454 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Thliveris, A. T. et al. Clonal construction of carcinogen-induced intestinal tumors in mice. Most cancers Prev. Res. (Phila.) 4, 916–923 (2011).

    Article 
    PubMed 

    Google Scholar 

  • Schenck, R. O. et al. The polyclonal path to malignant transformation in familial adenomatous polyposis. Most cancers Res. 83, 3497–3497 (2023).

    Article 

    Google Scholar 

  • Cross, W. et al. The evolutionary panorama of colorectal tumorigenesis. Nat. Ecol. Evol. 2, 1661–1672 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Greaves, M. & Maley, C. C. Clonal evolution in most cancers. Nature 481, 306–313 (2012).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Coorens, T. H. H. et al. Inherent mosaicism and intensive mutation of human placentas. Nature 592, 80–85 (2021).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nishimura, T. et al. Evolutionary histories of breast most cancers and associated clones. Nature 620, 607–614 (2023).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Hsu, S. H. et al. Multiclonal origin of polyps in Gardner syndrome. Science 221, 951–953 (1983).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • Becker, W. R. et al. Single-cell analyses outline a continuum of cell state and composition modifications within the malignant transformation of polyps to colorectal most cancers. Nat. Genet. 54, 985–995 (2022).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Michor, F., Iwasa, Y. & Nowak, M. A. Dynamics of most cancers development. Nat. Rev. Most cancers 4, 197–205 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Klein, A. M. et al. Droplet barcoding for single-cell transcriptomics utilized to embryonic stem cells. Cell 161, 1187–1201 (2015).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Kalhor, R., Mali, P. & Church, G. M. Quickly evolving homing CRISPR barcodes. Nat. Strategies 14, 195–200 (2017).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Westphalen, C. B. et al. Lengthy-lived intestinal tuft cells function colon cancer-initiating cells. J. Clin. Make investments. 124, 1283–1295 (2014).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Ludwig, L. S. et al. Lineage tracing in people enabled by mitochondrial mutations and single-cell genomics. Cell 176, 1325–1339 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Nam, A. S. et al. Somatic mutations and cell id linked by genotyping of transcriptomes. Nature 571, 355–360 (2019).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Vickovic, S. et al. Excessive-definition spatial transcriptomics for in situ tissue profiling. Nat. Strategies 16, 987–990 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wei, R. et al. Spatial charting of single-cell transcriptomes in tissues. Nat. Biotechnol. 40, 1190–1199 (2022).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wolock, S. L., Lopez, R. & Klein, A. M. Scrublet: computational identification of cell doublets in single-cell transcriptomic knowledge. Cell Syst. 8, 281–291 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Behjati, S. et al. Genome sequencing of regular cells reveals developmental lineages and mutational processes. Nature 513, 422–425 (2014).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Jombart, T., Balloux, F. & Dray, S. adephylo: New instruments for investigating the phylogenetic sign in organic traits. Bioinformatics 26, 1907–1909 (2010).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Deng, S. et al. A statistical methodology for quantifying progenitor cells reveals incipient cell destiny commitments. Nat. Strategies 21, 597–608 (2024).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Wang, Z. & Jaenisch, R. At most three ES cells contribute to the somatic lineages of chimeric mice and of mice produced by ES-tetraploid complementation. Dev. Biol. 275, 192–201 (2004).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Lawson, Okay. A., Meneses, J. J. & Pedersen, R. A. Clonal evaluation of epiblast destiny throughout germ layer formation within the mouse embryo. Growth 113, 891–911 (1991).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Patel, S. H. et al. Lifelong multilineage contribution by embryonic-born blood progenitors. Nature 606, 747–753 (2022).

    Article 
    ADS 
    CAS 
    PubMed 

    Google Scholar 

  • van Dijk, D. et al. Recovering gene interactions from single-cell knowledge utilizing knowledge diffusion. Cell 174, 716–729 (2018).

    Article 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Setty, M. et al. Characterization of cell destiny possibilities in single-cell knowledge with Palantir. Nat. Biotechnol. 37, 451–460 (2019).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Gulati, G. S. et al. Single-cell transcriptional variety is a trademark of developmental potential. Science 367, 405–411 (2020).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Haber, A. L. et al. A single-cell survey of the small intestinal epithelium. Nature 551, 333–339 (2017).

    Article 
    ADS 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Fazilaty, H. et al. Tracing colonic embryonic transcriptional profiles and their reactivation upon intestinal harm. Cell Rep. 36, 109484 (2021).

    Article 
    CAS 
    PubMed 

    Google Scholar 

  • Cañellas-Socias, A. et al. Metastatic recurrence in colorectal most cancers arises from residual EMP1(+) cells. Nature 611, 603–613 (2022).

    Article 
    ADS 
    PubMed 

    Google Scholar 

  • Liu, Y. et al. Comparative molecular evaluation of gastrointestinal adenocarcinomas. Most cancers Cell 33, 721–735 (2018).

    Article 
    CAS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Muyas, F. et al. De novo detection of somatic mutations in high-throughput single-cell profiling knowledge units. Nat. Biotechnol. 42, 758–767 (2024).

  • Dou, J. et al. Single-nucleotide variant calling in single-cell sequencing knowledge with Monopogen. Nat. Biotechnol. 42, 803–812 (2023).

  • Tukiainen, T. et al. Panorama of X chromosome inactivation throughout human tissues. Nature 550, 244–248 (2017).

    Article 
    ADS 
    PubMed 
    PubMed Central 

    Google Scholar 

  • Wu, T. et al. clusterProfiler 4.0: a common enrichment device for decoding omics knowledge. Innovation (Camb.) 2, 100141 (2021).

    CAS 
    PubMed 

    Google Scholar 

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